Objective To explore the nutrient requirements and compound the feed scientifically for Mugilogobius chulae. Methods The flesh content and nutritional component in the adult fish muscle were measured by conventional methods. Results The flesh content of adult fish were (65.20±3.82) %. Those contents of moisture, crude protein, crude fat and crude ash in the fresh muscle were (79.40±0.03) %, (17.54±0.31) %, (0.62±0.09) %, (2.34±0.07) % , respectively. The limited amino acids were Trp, (Met + Cys). The contents of EPA and DHA in fatty acids of M. chulae were lower. Conclusion Artificial feeds for M. chulae should low the crude fat content and add Trp, Met, Cys, and marine algae such as diatom, brown and red algae.