【Abstract】 Objective To observe the anesthetic effect of ketamine combined with alcohol on experimental dogs in state of swaying naval vessels. Methods 34 dogs were divided into group Ⅰ(n=10,in state of static naval vessels) and group Ⅱ（n=24,in state of swaying naval vessels）. The dog in two groups was anesthetized by ketamine respectively, then alcohol was given by intravenous drip. The anesthetic effect was recorded. Results The induction time of basal anesthesia for ketamin in group Ⅰwas no significant difference than that in group Ⅱ（P﹥0.05）.The anesthesia of ketamine can ensure the accomplishment of skin preparation and placement of venous trocar for dogs, and the anesthesia can be maintained with alcohol continuous infusion．Anesthetic effect was divided into good，moderate，bad，and death according to the reaction of dogs，and the anesthetic effect rate（good＋moderate）were 100% in two groups. Conclusions The anesthetic effect of ketamine combined with alcohol on dogs is safe，effective for the anesthesia on experimental dogs in state of swaying naval vessels．