Objective To discuss the change of pathology and biochemical indexs during the building the Mini-pig model of hepatic cirrhosis. Method The subjects were 50 Bama mini-pigs of the same germline, who were divided at random into a experiment group of 40 and a control group of 10, male or female, aged 4 months, weighing 15-20 kg. Composite factors were employed to establish a model for the experiment group, and the normal feeding was synchronically given to the controlled. At 0th、4th 、8th、12th、16th、20th、24thWeekend，the liver puncturation biopsy and the haemospasia by the ear venous were done. Result At 24thWeekend, the normal group was 70 cases, the slight hepatic fibrosis（stage S1＋S2） was 82 cases, the severe hepatic fibrosis（stage S3＋S4）was 62 cases, and the hepatic cirrhosis was 33cases. From normal to cirrhosis groups, ALT、AST、T.BIL、CR and GLO of the pathological models rose gradually, ALB decreased gradually and A/G ratio was inversion, PT prolonged gradually, there were statistically significant in groups(p<0.01). Conclusion The model-building from composite factor food of carbon tetrachloride (CCL4) can establish successfully the models of Mini-pigs liver cirrhosis. The pathology and biochemical indexs change obviously in different stage of hepatic fibrosis.