Objective To investigate the effects of a Chinese medicine, Mai Qi Jiang Tang pill,on the bloodglucose level in ob/ ob mice. Methods Eight-week old male ob/ ob mice were randomly divided into Mai Qi Jiang Tang pillhigh (8 g/ kg), medium (4 g/ kg), and low (2 g/ kg) dose groups, as well as a metformin (250 m g/ kg) group, wereorally administered drugs once daily for 10 weeks. Age-matched C57BL/6 J control mice and ob/ ob mice were orallyadministered an equal volume of vehicle. Average food consumption per day and body weights of the mice were recorded,and fasting blood glucose and insulin levels were measured using a glycemic instrument and enzyme-linked immunosorbentassay, respectively. Pathological changes of the pancreas were observed using hematoxylin and eosin staining. Results Compared with the control ob/ ob mice, ob/ ob mice administered Mai Qi Jiang Tang pill exhibited significantly decreasedfasting blood glucose levels at 2, 6, 8, and 10 weeks after treatment ( P < 0. 05, P < 0. 01). Mai Qi Jiang Tang pill alsoattenuated the degree of pathological changes observed in islet cells and increased serum insulin levels ( P < 0. 05), butelicited no significant difference in body weight or average food consumption per day at 10 weeks after treatment.Conclusions Mai Qi Jiang Tang pill can decrease blood glucose levels of ob/ ob mice, which may be related to the amelioration of pancreatic pathology and promotion of insulin secretion.