Functional dyspepsia (FD) is a common clinical gastrointestinal functional disease. Establishment of an FD rat model will facilitate in?depth study of the disease. The primary method to induce the model employs single factors, but its limitations become obvious when the etiology of FD has been researched continually. However, compound factors have been gradually applied to induce the model, because they have the advantage of variously simulating the etiology.