Long non-coding RNA (LncRNA) has attracted increasing attention over the recent years. It is closely related to the occurrence and development of human diseases based on numerous academic researches. Analysis of the biological function of LncRNA in depth may lead to great breakthroughs in clarifying pathogenesis of many diseases and provide possible targets for intervention. Recent studies have revealed the importance of LncRNA in the progression of heart failure (HF), the final stage of many cardiovascular diseases. This review summarized the new findings of LncRNA in prognosis and treatment of HF.