Objective To study quail high uric acid hematic disease animal model and lipid metabolism.Methods Quail were used high fat feed after thirty days, gastric gavage adenine(50 mg/only)seven days in a row. Quail high uric acid hematic disease animal model was set up.Observed in twenty-two days,blood was tested blood uric acid,xanthine oxidase, creatinine(CRE),urea nitrogen(BUN),triglycerides(TG),low density lipoprotein cholesterol(LDL-c), hight densitry lipoproteon(HDL),xanthine oxidase(XOD),hepatic lipase(HL),lipoprotein lipase(LPL),adenosine dehydrogenase(ADA)lipid metabolism index,joints and kidneys for histopathological examination.Results Model control group animals blood uric acid were significantly increased(P<0.01), CRE,BUN,TG, LDL and XOD were significantly increased(P<0.05 or P<0.01), serum CHO、LPL、ADA、HDL content significantly decreased(P<0.05).Animal toes jointed obvious swollen after building, surrounding soft tissue swelling. X-ray showed toes bone density decrease, part of the joint surface damage is dissolved bony destruction. Pathological examination showed joint synovial hyperplasia, there was a lot of inflammatory cells infiltration, part is replaced by fibrous connective tissue, Kidney tissue renal tubule and interstitial visibled urate crystals, part of the tubular mild expansion,renal interstitial fibers hyperplasia, accompanied by a large number of inflammatory cells infiltration. Conclusion The model has swollen joints, kidney urate deposition kidney injury associated with lipid metabolism disorders, pathological mechanisms and XOD increased ADA.