Objective To investigate if there are differences in hematological indexes between BALB/c mutant curly mice and normal BALB/c mice.Methods 6 week old BALB/c mutant curly and normal BALB/c mice of each 20(male and female)were selected,and 8 blood routine indexes and 15 serum electrolytes and biochemical indexes were detected using automatic blood cell analyzer and automatic biochemical detection,and the results of two groups were compared.Results The sex and group results of WBC,MCV,PLT and MCHC between BALB/c mutant curly mice and normal mice have significant differences(P<0.05,P<0.01);the sex and group results of Na⁺、K⁺ and Cl-between BALB/c mutant curly mice and normal mice have significant differences(P<0.05,P<0.01);the sex and group results of ALT、GLU and TG between BALB/c mutant curly mice and normal mice have significant differences(P<0.05,P<0.01).Conclusion Some hematological indexes between BALB/c mutant curly and normal BALB/c mice are different clearly,and these results will provide the theoretical references for researching and using mutant curly mice model.