Objective To study on the anti-hepatic fibrosis effects of salvianolic acid A injection (SAA), and further to provide the theoretical basis for the clinical application. Methods Using CCl₄ induced hepatocyte injury in vitro, the hepatocyte viability, the levels of ALT, AST and LDH in cell culture supernatants and the levels of SOD and MDA in cell lysates were detected. In addition, the hepatic fibrosis rat model was made by subcutaneous injection of CCl₄, the serum LN, HA, SOD and MDA levels were detected and the pathological changes in liver tissue were also observed. Results Compared with model group, the hepatocyte viability in SAA high or low dose group and Vit E group were significantly increased (P< 0.01), and the activities of ALT, AST and LDH in SAA high dose group were significantly lowed (P< 0.01). The activity of SOD in SAA high dose group and Vit E group was significantly increased (P< 0.05), while MDA content was decreased (P< 0.05). Vivo test showed that the levels of serum LN and HA in SAA high dose group were significant lower than those of hepatic fibrosis rat model group (P< 0.05). Moreover, the activity of SOD in SAA high or low dose group was significantly increased (P< 0.05,P< 0.01), while MDA content was lowed (P< 0.05,P< 0.01), and can improve the pathological of liver tissues. Conclusions SAA injection can anti-lipid peroxidation and thereby protect hepatocyte and reduce hepatic fibrosis.