Objective To measure the range of routine blood counts and blood biochemical parameters,to analyze hemorheology of the rats with congenital cataract. Methods Blood samples were taken from 90 rats with congenital cataract weight about 185~211 g.Routine blood analysis was performed and blood biochemical and hemorheology paramenters were determind using an automatic blood biochemical and hemorheology analyzer. Results There were no significant difference (P > 0.05) between the cataract rats and the normal rats in Blood test results; but there were significant difference between the microphthalmos cataract rats and the normal same-sex rats (P< 0.01 or P< 0.05). The biochemical results is the cataract rats and the normal rats were different significantly in ALB group (P< 0.01 or P< 0.05), and the female microphthalmos cataract rats compared with the control rats had significant difference in Ure (P< 0.01), the female cataract rats ompared with the normal rats were very significant difference in Cr group(P< 0.05 or P< 0.01).The erythrocyte counts of the male cataract rats and male microphthalmos cataract rats were significantly lower than that in the female ones, respectively(P< 0.05, P< 0.01).The platelet counts of the male cataract rats and the male microphthalmos cataract rats were significantly higher than that in the female ones, respectively(P< 0.01), and the creatinine of the male cataract rats and the male microphthalmos cataract rats were significantly lower then that in the female ones, respectively(P< 0.01). There were no significant difference in every group on hemorheology.Conclusions There were significant differences in some blood indexes between the congenital cataract rats and the normal rats. These data may become useful reference for biomedical researcher in this field.