Objective To improve the preparation of rabbit models bearing VX2 hepatoma for interventional therapy study, and to investigate their CT features.Methods Eighty New Zealand white rabbits were implanted with VX2 hepatoma in the deep aspect of the left lobe of liver. CT scanning was performed in the experimental animals at 1, 2 and 3 weeks after implantation. The plain, early arterial phase and portal phase images were obtained. Results Twenty-four (100%) rabbits were successfully implanted with VX2 hepatoma in the liver. On CT scans taken at 2 weeks after implantation, the tumors showed most clear and typical images: 1-2 cm in diameter, hypodensity or isodensity on plain CT scans, markedly enhanced early arterial phase images, hypodensity on portal phase images, well discernible from the surrounding liver tissues. Hepatic angiography showed that the tumor was hypervascular. Necrosis was seen in most animals at 3 weeks after implantation. Conclusions The rabbit model bearing VX2 hepatoma is more suitable for interventional therapy study. CT is very useful in evaluating the tumors.