Objective To observe the effect of high fat diet on the lipid metabolism and the formation of atherosclerosis in Tibetan Pig in order to discuss the characteristics of the insulin resistance atherosclerosis model of Tibetan Pig. Method Several 4-5 months age Tibetan Pigs were randomly divided into normal group 4 ones which were fed with common diet and AS model group 8 ones which were fed with high fat diet for 24 weeks. At the time of before the modeling and the 4th、8th、12th、16th、20th、24th week blood was regularly taken from precaval vein, then measured fasting plasma glucose, fructosamine, blood lipid and serum insulin level and conduct glucose tolerance test, calculated the atherogenic index(AI), insulin resistance index(HOMA-IR), insulin sensitivity index(HOMA-IS). Animals were anesthetized to meare arterial blood pressure and indices of left ventricular function. Abdominal aortic was taken to observe the plaque, HE staining and oil red "O" staining was conducted to observe the pathological changes. Result Controlled with normal group, the fasting plasma glucose of AS model group increased significantly since 16th week(P < 0.05,P < 0.01), the fructosamine increased significantly since 4th week(P < 0.01), the lipid level also increased significantly from 4-24th week, atherogenic index(AI) increased significantly from 4-24th week. During the 16-24th week the HOMA-IR of the model group was significantly high and the HOMA-IS was significantly low(P < 0.05,P < 0.01). At the 24th week, controlled with the normal group, the MBP and SBP of the model group was significantly high(P < 0.05,P < 0,01) while the LVEDP、+dp/dtmax、-dp/dtmax was significantly changed(P < 0.05,P < 0.01). Pathological observation showed that in the AS model group there is lipid deposition and atherosclerosis appeared. Conclusion Tibetan Pig induced by high fat diet can appear obvious atherosclerosis and insulin resistance, hypertension, hyperlipidemia, impaired glucose tolerance, which is an ideal experimental animal of the study of insulin resistance atherosclerosis.