ObjectiveTo set up a conscious model of vascular headache by electrical stimulation of the superior sagittal sinus and to verify its reliability and feasibility, we observed the behavioral changes of conscious rats which were administrated two classical analgesic drugs that acetaminophen and ibuprofen. Methods30 male SD rats were randomly divided into three groups:control group (saline group), acetaminophen group and ibuprofen group. Each group was given electrical stimulation 5 minutes before and 40 minutes after administrated. The number of head- flicks and excessive grooming times were observed as the main parameters. ResultsThere were significant decrease on head- flicks and excessive grooming between the control group and the administration-group (P<0.05), while no significant difference between the acetaminophen group and the ibuprofen group. ConclusionParacetamol and ibuprofen can significantly relieved the symptoms of the headache in this models by administrated. This conscious rat headache models was practical and reliable model.