ObjectiveTo study the hepatic pathological changes in SD rat hepatic fibrosis model caused by carbon tetrachloride(CTC), alcohol combined with CTC, bile duct ligation, and discuss the pathogenesis of hepatic fibrosis preliminarily. Methods SD rats in carbon tetrachloromethane group were injected 50% carbon tetrachloromethane (CTC∶Olive oil=1∶1) hypodermically with dosage of 3 mg/kg (first dose doubled),2 times every week, for 6 weeks continuously. SD rats in alcohol combined with CTC group were drenched daily by alcohol mixture (alcohol∶pyrazole∶corn oil=10 mL∶25 mg∶2 mL) with dosage of 10 mL/kg, at the same time, intraperitoneal injected with dosage of 3 mg/kg CTC∶Olive oil(1∶3) 2 times every week,for 6 weeks continuously. SD rats in bile duct ligation group were anesthetized by 3% pentobarbital sodium intraperitoneal injection with dosage of 10mg/kg body weigh, disinfected abdominal skin, cutted along the abdomen to separate the bile duct and ligate bile duct at the proximal and distal bile duct with aseptic technique,28 days later ended the experiment. After the test, we anesthetized SD rats, dissected liver tissues with 10% formalin fixed for pathological inspection. Conclusions SD rat hepatic fibrosis model induced by CTC characterized by diffuse fatty liver, hepatitis and hepatic fibrosis; SD rat hepatic fibrosis model induced by alcohol combined with CTC characterized by alcoholic fatty liver, hepatitis and hepatic fibrosis; SD rat hepatic fibrosis model induced by bile duct ligation characterized by bile duct hyperplasia, hepatitis and hepatic fibrosis. ResultThese three methods can cause hepatic fibrosis occurs, in which the method for SD rat hepatic fibrosis model caused by CTC is suitable for clinical cholestasis induced hepatic fibrosis model to establish, the other two methods are suitable for chemical, viral hepatitis induced hepatic fibrosis model to establish, we can choose different method to establish corresponding animal model according to different experiment purpose.