Objective To explore the role of high mobility group box 1(HMGB1) in ventilator-induced lung injury(VILI) by investigating the expression of HMGB1 mRNA and protein in the lung of rats with mechanical ventilation at different tidal volumes.Methods Twenty-four male Wistar rats were randomly divided into three groups:control group,low tidal volume group(L-VT ),high tidal volume group(H-VT ).Immunohistochemial staining and molecular hybridization in situ were employed to determine the expression level of HMGB1 ...