Abstract:The vaccines are considered as an useful approach for preventing the AIDS.Most of the past HIV vaccines only induced the body to product the memory B cell and antibody,but don't to prevent HIV from infecting the body.The strategy on development of vaccines against HIV basing on memory T cells could bring new hope to human vaccination.In this review,the classification,differentiation,formation and duration of memory cells,and also the possible target role for development vaccines will be presented.