The reptiles can generate prompt and powerful antibody response to either soluble or particulate antigens.High molecular weight immunoglobulin and more than one low molecular weight immunoglobulins have been found in the serum of the reptiles.Transmission of specific immunoglobulins(IgY) from mothers to their offspring via the egg has been proven recently.Salt out of saturated(NH_4)_2SO_4,exclusion chromatography,ion exchange chromatography and protein A affinity chromatography were usually used in the purification for immunoglobulins of reptiles.The research for Humoral immunity in reptiles has significance to the evolution of animal immunology and the control for pathogeny.