Objective To measure the organ weight and calculate organ coefficient of db/db and /db mice.Methods 2-3 month old db/db 20 and /db20 mice,26 mice in each group,were used in this experiment.The weight of various organs was measured using a Sartorius BP121S electronic balance.Results Between female db/db and /db mice,the heart and spleen weight showed significant difference(P<0.05),the liver,kidney,brain,pancreas,adrenal and uterus weight showed very significant difference(P<0.01).Between male db/db and /db mice,the liver,brain and testis weights showed very significant difference(P<0.01).Between db/db and /db mice,the coefficient of liver and lung had significant difference(P<0.05),the coefficient of spleen,brain,pancreas,uterus and testis showed very significant difference(P<0.01). Between female and male db/db mice,the heart,kidney,pancreas and adrenal weight had very significant difference(P<0.01),the liver weight had significant difference(P<0.05);but similar weight of the spleen and lung(P>0.05).Between female and male /db mice,the kidney weight had very significant difference(P<0.01),the pancreas weight had significant difference(P<0.05),but no significant difference was seen in other organs(P>0.05).Conclusion The weight of some main organs and organ coefficient in db/db, /db and same genotype different gender mice are significantly different.