IVC system is a kind of modes of feeding laboratory animals,being developed rapidly in the world at present.This mode have advantages such as safe and economy,etc.This article will introduce an overview of the progress both at home and abroad from several aspects: the system supplies gas and exhausts;the air quality in the box,the transmission and detection of microorganisms,physiology and breeding of experimental animals,etc.Finally,to look forward the future application of IVC system in our country.