The study was carried out to assess the effects of Paolifen on the activities of Super oxide Dismutase (SOD) and the contents of Lipid Peroxidize (LPO) of rat,The activities of SOD was determined with fast method.And malondialdehyde (MDA) was determined by TBA fluorescence,The SOD activities of rat liver and serum was a significant increase in the experimental groups of Paolifen (P<0.05).The contents of LPO in three groups taking Paolifen were much lower than that of the control group.It is suggested that Paolifen have an action of anti oxidate,scavenging the free radicals.