Research progress of intestinal flora immunomodulation combined therapy for colorectal cancer
Received:September 07, 2021  
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DOI:10. 3969 / j.issn.1005-4847. 2022. 03. 018
KeyWord:intestinal flora; colorectal cancer; immunoregulation; combined treatment; animal models
李惠 1. 延安大学基础医学院,陕西 延安 ;2. 空军军医大学实验动物中心,西安
赵菊梅 延安大学基础医学院,陕西 延安
师长宏 空军军医大学实验动物中心,西安
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      Intestinal flora form a specialized immune microenvironment that affects the occurrence and development of colorectal cancer through immunoregulation. Here, we review the research progress of intestinal flora in immune regulation therapy for colorectal cancer and summarize the relationship between intestinal flora and host or tumor immunity. Moreover, we analyzed the result of related animal experiments and clinical trials and introduce the mechanism and strategy of combination therapy based on intestinal flora immunomodulation for the treatment of colorectal cancer. Thus, this review may provide a reference for the treatment of colorectal cancer.
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