Progress in research into animal models of systemic lupus erythematosus encephalopathy
Received:February 04, 2021  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 04. 014
KeyWord:Systemic Lupus erythematosus encephalopathy; animal models; mice
           
AuthorInstitution
王赛雯 南京大学生命科学学院,南京
梁军 南京大学医学院附属鼓楼医院 风湿免疫科,南京
侯亚义 南京大学医学院,南京
窦环 南京大学医学院,南京
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Abstract:
      Systemic lupus erythematosus encephalopathy (NPSLE) is a nervous system complication of systemic lupus erythematosus (SLE). Various animal models of NPSLE have been developed that are characterized by histological defects, such as neuronal apoptosis and fewer synapses; brain leukocyte infiltration; and behavioral defects, such as emotional abnormalities and impaired learning and memory. In this article, we summarize the method used to construct animal models of NPSLE, describe the principal characteristics of each, and discuss the use of these models in the study of the pathogenesis of the disease and the identification of potential therapeutic targets. These models are useful means of defining the pathogenesis of NPSLE, screening potential therapies, and developing techniques for personalized diagnostic and treatment plans.
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