Recent progress in research on the effects of interleukin-37 in severe pneumonia caused by influenza virus infection
Received:July 24, 2020  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 01. 014
KeyWord:influenza virus; severe pneumonia; cytokine storm; IL-37
        
AuthorInstitution
刘明娅 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病 比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物 模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京
戚菲菲 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病 比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物 模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京
鲍琳琳 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病 比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物 模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京
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Abstract:
      Influenza is a highly contagious acute respiratory infectious disease, which has a wide prevalence and high morbidity. Aggressive innate immune responses often induce a cytokine storm, which is associated with elevated levels of inflammatory cytokines, causing lung damage and failure. Severe pneumonia is one of the major causes of death of influenza patients. Currently, the drugs that are clinically used for influenza treatment are mainly antiviral drugs. However, these drugs usually cannot regulate the excessive immune response of the body or reduce lung damage. IL-37, a member of the IL-1 family, has a strong anti-inflammatory function. By inhibiting the secretion of a variety of inflammatory cytokines, IL-37 prevents the occurrence of cytokine storms and plays an important role in infectious diseases, autoimmune diseases and tumors. Therefore, if the anti-inflammatory effects of IL-37 can be applied to the treatment of severe pneumonia caused by H1N1 influenza virus infection, this strategy will undoubtedly provide new directions for the treatment of patients with severe pneumonia.
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