Hemophilic arthropathy is caused by spontaneous intra-articular hemorrhage and repeated intra-articular hematomas. Chronic pain, joint damage and decreased quality of life are the main clinical manifestations of hemophilic arthropathy. The biological mechanisms are not fully understood. Current translational animal models of hemophilia are of great value in determining the pathophysiology of the disease and its complications. Therefore, a hemophilic arthropathy mouse model was established to further investigate the pathophysiological mechanisms of hemophilic arthropathy as well as potential intervention treatments. A murine model of hemophilia provides advantages as an animal model for research because of easy transportation and easy construction,and its constructed hemophilic arthropathy model also provides the basis for future clinical research. This review will describe the construction and investigation of a mouse model of hemophilia arthropathy.