Olfactory working memory impairment in the transgenic mice at very early stage of Alzheimer’s disease
Received:May 10, 2018  
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DOI:10.3969/j. issn. 1005 - 4847. 2018. 04. 005
KeyWord:Alzheimer's disease; odor span length; transgenic mice; working memory
                    
AuthorInstitution
张记春 北京大学第六医院,北京大学精神卫生研究所,国家精神心理疾病临床医学研究中心,痴呆诊治转化医学研究北京市重点实验室,北京
黄庚娣 北京大学第六医院,北京大学精神卫生研究所,国家精神心理疾病临床医学研究中心,痴呆诊治转化医学研究北京市重点实验室,北京
孟雪 北京大学第六医院,北京大学精神卫生研究所,国家精神心理疾病临床医学研究中心,痴呆诊治转化医学研究北京市重点实验室,北京
田永路 北京大学前沿交叉学科研究院生命科学联合中心,北京
于欣 北京大学第六医院,北京大学精神卫生研究所,国家精神心理疾病临床医学研究中心,痴呆诊治转化医学研究北京市重点实验室,北京
张晨 北京大学生命科学学院,北京
王华丽 北京大学第六医院,北京大学精神卫生研究所,国家精神心理疾病临床医学研究中心,痴呆诊治转化医学研究北京市重点实验室,北京
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Abstract:
      Objective To explore the characteristic impairments of olfactory working memory in the transgenic mice at very early stage of Alzheimer’s disease (AD). Methods Nine pairs of 5?week?old male 5XFAD mice and their wild?type littermates, and 8 pairs of 9?week?old male 5XFAD mice and their wild?type littermates were used. The study animals underwent the odor span test after extensive training. The odor span length, the number of errors and the accuracy rate of odor discrimination were used to evaluate the olfactory working memory. Results Compared with the wild?type group, the 9?week?old transgenic mice presented significantly shorter odor span length ( P < 0. 05), more errors ( P <0. 05) and lower accuracy ( P < 0. 05) of odor discrimination. Besides, the 9?week?old transgenic mice exhibited significantly shorter odor span length than the 5?week?old transgenic mice ( P < 0. 05). However, there were no significant differences in the odor span length, the number of errors and the accuracy between the 5?week?old transgenic and wild?type mice ( P > 0. 05). Conclusions Olfactory working memory is impaired in the 9?week?old transgenic 5XFAD mice. It suggests that the olfactory working memory impairment might be considered as a sensitive indicator of very early cognitive impairment in the 5XFAD mice.
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