Objective HGF and its receptor (c-met) are principal mediators of mesenchymal-epithelial interaction in several different systems. Moreover, hair follicle is a model of mesenchymal-epithelial interaction. The aim of this study was to explore whether HGF/c-met signal plays a role in the control of hair follicle growth cycle. Methods To examine the localization of HGF/c-met in anagen, catagen and telogen in the hair follicle of ICR mice. Results HGF was mainly located in the dermal papilla and sebaceous gland, and c-Met in the hair matrix, root sheath and epidermis. Both HGF and c-met expressions peaked during anagen, not found in catagen, and increased during telogen-anagen phase. Conclusions Our results demonstrate a regulatory role of HGF and c-met in the control of hair follicle growth in ICR mice.