Application of Chinese Bama minipigs in medical research:a literature review
Received:September 30, 2013  
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DOI:10.3969/j.issn.1005-4847.2014.01.020
KeyWord:Minipigs;Bama minipigs;Animal models
        
AuthorInstitution
庞琳琳 辽宁中医药大学, 沈阳
张会永 辽宁中医药大学附属医院, 沈阳
杨关林 辽宁中医药大学, 沈阳
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Abstract:
      As one of the major domestic minipig strains, Guangxi Bama minipigs have the following characteristics: genetic stability, fecund species, lighter weight, large area of body surface covered with white hairs, many tissues and organs and biochemical indicators similar to those of humans and so on. All these characteristics make them being widely applied in medical research. Because of the similar anatomy and physiology in cardiovascular system, Bama minipigs have been used in the research of cardiovascular system. In our country, Bama minipigs are used for establishing models of cardiovascular diseases such as myocardial ischemia, patent foramen ovale and so on. Pigs are omnivore-animals and similar to human beings in lipid metabolism, so they can be used in the study of endocrine diseases. Bama minipigs have been used in modeling, genetic susceptibility and complication prevention of diabetes. Bama mini-pigs' digestive system is similar to that of humans, so they can be used as a model of digestive system diseases including chronic pancreatitis, rupture of colon and bilioenteric anastomosis. The aspect that large area of their body surface is covered with white hairs except their head and tail makes them ideal model of skin wound and healing of burns. Bama minipigs can be used for stomatological research for their similarity to human beings in the structure of the teeth and large crack. Bama minipigs have been applied for the research of pulp necrosis and the way of maxillary expansion. They are similar to human beings in anatomy, physiology and pathology, which makes them an appropriate provider for zenotransplantation. In the research of traditional Chinese medicine, Bama minipigs has been used as liver, spleen and femoral arteriovenous fistula hemorrhagic model to study curative effect and mechanism of traditional Chinese preparation.
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