Urinary metabonomic variation in type 2 diabetic rats
  
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KeyWord:Type 2 diabetes;Rat;high-fat;High-sucrose diet;Streptozotocin;Metabonomics;
YUAN Lin,BAI Yong-sheng,ZHOU Ming-mei,HU Na,LU Xiong
YUAN Lin,BAI Yong-sheng,ZHOU Ming-mei,HU Na,LU Xiong(Experiment Center of Science and Technology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
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Abstract:
      Objective To investigate the urinary metabonomic variation in diabetic rats in order to explore the ap-plication of metabonomics in research of diabetes.Methods Male Sprague-Dawley rats were fed with high-fat and high-su-crose diet for 6 weeks and then injected with vehicle or streptozotocin(STZ) in a dose of 37 mg /kg.Fasting blood glucose(FBG) was monitored weekly after STZ injection.Urines of normal rats and model rats were collected at 1,2,4,6,8 weeks after STZ injection.Serum insulin(INS),triglyceride(...
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