Objective To establish a manipulation-easy animal model of post-ischemic myocardial fibrosis and in-vestigate the mechanism of collagen deposition.Methods Twenty BALB /c mice were randomly divided into two groups: the experimental group and control group.The mice in the experimental group were subjected to hypodermic injection with isoproterenol in a dose of 50 mg /kg.The injection was carried out twice a day for consecutive 10 days.Physiological saline was injected with the same method in the control group...