Establishment of a mouse model of myocardial fibrosis with isoproterenol and the mechanism of collagen deposition
  
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KeyWord:Isoproterenol;Myocardial fibrosis;Mouse;Animal model;
DENG Wei,CHEN Qing-wei,LI Xing-sheng,LI Gui-qiong,KE Da-zhi,MO Xian-gang
DENG Wei,CHEN Qing-wei,LI Xing-sheng,LI Gui-qiong,KE Da-zhi,MO Xian-gang(Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
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Abstract:
      Objective To establish a manipulation-easy animal model of post-ischemic myocardial fibrosis and in-vestigate the mechanism of collagen deposition.Methods Twenty BALB /c mice were randomly divided into two groups: the experimental group and control group.The mice in the experimental group were subjected to hypodermic injection with isoproterenol in a dose of 50 mg /kg.The injection was carried out twice a day for consecutive 10 days.Physiological saline was injected with the same method in the control group...
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