Objective The purpose is providing some scientific bases for further research of nutriology and nutritional disease science on molecular biological level by studying on functions of mouse genes relative to feeding amount,drinking amount and protein metabolism. Method\ Employing antisense oligo nucleotide technology and animal behavioral tests,the authors studied gene function relative to animal meals and nutritional metabiosm on the whole body level of animal.The authors selected four genes having obvious differences of feeding amount with control groups in the past research,and used BALB/c mice to do experiments.Results\ The feeding and drinking amounts of D1,Pe and Tr antisense groups have obvious differences with control groups,and the proteins metabolism of D1 and Tr antisense groups have obvious differences with control groups.The feeding and drinking amount of D1 is much greater than control groups and the tendency is downwards,but the apparent digestibility is lower than control groups.This indicates that its function of proteins metabolism is dropping.The feeding and drinking amount of Tr is also much greater than control groups but the tendency is upwards and the apparent digestiblity is greater than control groups.This illustrates that its function of proteins metabolism is going up.Conclusion D1 gene is probably relative to improving nutritional metabolism function and Tr gene has the function of inhibiting nutritional metabolsim.Moreover,D1,Pe and Tr are relative to other behavior such as locomotion,sense of pain and memory;P3 has no relation to other behavior.