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齐莉莉,刘宏,李剑.呼吸道合胞病毒感染动物模型的构建与评价[J].中国实验动物学报,2022,30(7):989~995.

呼吸道合胞病毒感染动物模型的构建与评价

Construction and evaluation of animal models of respiratory syncytial virus infection

投稿时间：2022-01-25

DOI：10. 3969 / j.issn.1005-4847. 2022. 07. 015

英文关键词:respiratory syncytial virus animal model vaccine lung injury

基金项目:

作者	单位
齐莉莉	河北医科大学教学实验中心,石家庄 050017
刘宏	河北医科大学第二医院,石家庄 050000
李剑	河北医科大学基础医学院,石家庄 050017

Author Name	Affiliation
QI Lili	Teaching Experiment Center of Hebei Medical University, Shijiazhuang 050017, China
LIU Hong	the Second Hospital of Hebei Medical University, Shijiazhuang 050000
LI Jian	Basic Medicine College of Hebei Medical University, Shijiazhuang 050017

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中文摘要:

人类呼吸道合胞病毒(human respiratory syncytial virus,hRSV)是在世界范围内引起呼吸道疾病和婴儿住院的主要原因。目前尚无有效的 hRSV 疫苗或治疗药物。针对 hRSV 易感人群的候选疫苗已经处于开发阶段,因此 hRSV 的动物模型在 hRSV 候选疫苗的临床前试验中发挥着重要作用。尽管许多模型在临床前研究中显示了有效性,但很少有模型进入临床试验,或者它们的成功率较低。这在一定程度上是由于缺乏完全重现人类hRSV 感染发病机制的动物模型。本文分析了 hRSV 动物模型的优点和局限性,包括用 hRSV 感染非人类哺乳动物宿主,以及非人类肺病毒动物模型的研究进展,以期为 hRSV 感染动物模型的合理构建提供思路。

英文摘要:

Human respiratory syncytial virus ( hRSV) is a major cause of respiratory disease and infant hospitalization worldwide. At present, there is no effective hRSV vaccine or therapeutic drug. A candidate vaccine for the hRSV susceptible population is currently being developed, and an animal model of hRSV would therefore play an important role in the preclinical trials of a hRSV candidate vaccine. Although many models have shown effectiveness in preclinical studies, few have entered clinical trials and their success rate has been low. Animal models to date have been unable to fully reproduce the pathogenesis of hRSV infection. Here, we analyze the advantages and limitations of hRSV animal models, including the use of hRSV to infect non-human mammalian hosts and the development of non-human pulmonary virus animal models. The aim of this review is to provide a rational strategy for the construction of an effective animal model of hRSV infection.

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