Hypertriglyceridemia ( HTG) has become a research hotspot because it is tightly associated with obesity, metabolic syndrome and diabetes,and is also one of the important factors of inducing acute pancreatitis (AP) and increasing the risk of atherosclerotic cardiovascular disease ( ASCVD). The success of replicating animal model of hypertriglyceridemia is one of the key of research in experimental hypertriglyceridemia. The paper summarizes the research of hypertriglyceridemia animal model in order to provide reference for studying in-depth mechanism and selecting antilipidemic drugs.