This study reviewed the effects and physiological response mechanisms of high +Gz exposure on thecardiovascular, respiratory, central nervous and endocrine systems and other tissues and organs, and to discuss if these results and theoretical mechanisms could be adapted to human body. The results showed that high +Gz has a significantimpact on the blood circulation in the whole body and various organs, resulting in ultrastructural alterations of thecardiovascular system, lung tissue, endocrine glands and brain tissue, etc. With the application of radioimmunoassay andbiochemical method, mechanical finite element model, gene chip and other technologies, better understanding of the physiological stress response and pathogenic mechanism under high +Gz load will be achieved.