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于加倍,胡扬,李燕春,梅涛,韩天雨,白学成,付鹏宇,朱镕鑫,车欣媛.4 周爬梯抗阻训练对低氧诱导大鼠骨骼肌萎缩的影响[J].中国实验动物学报,2018,26(4):448~453.
4 周爬梯抗阻训练对低氧诱导大鼠骨骼肌萎缩的影响
Effects of 4?week resistance training on hypoxia?induced skeletal muscle atrophy in rats
投稿时间:2018-04-04  
DOI:10.3969/j. issn. 1005 - 4847. 2018. 04. 007
中文关键词:  SD 大鼠  骨骼肌萎缩  低氧  爬梯抗阻训练
英文关键词:SD rats  skeletal muscle  atrophy  hypoxia  resistance training
基金项目:国家自然科学基金面上项目(No. 31771317)
作者单位E-mail
于加倍 北京体育大学,北京 100084 1115247588@ qq. com 
胡扬 北京体育大学,北京 100084 hyyr1@163; com 
李燕春 北京体育大学,北京 100084  
梅涛 北京体育大学,北京 100084  
韩天雨 北京体育大学,北京 100084  
白学成 北京体育大学,北京 100084  
付鹏宇 北京体育大学,北京 100084  
朱镕鑫 北京体育大学,北京 100084  
车欣媛 北京体育大学,北京 100084  
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中文摘要:
      目的 探究抗阻训练抵抗低氧诱导骨骼肌萎缩的效果,为解决高原训练期间运动员骨骼肌丢失问题提供理论依据?方法 8 周龄雄性Sprague?Dawley(SD)大鼠24 只,平均体重约230 g,随机分为4 组:常氧安静组 (C)?常氧抗阻训练组(R)?低氧安静组(H)和低氧抗阻训练组(HR)?H 和HR 组在模拟海拔4000 m,R 和HR 组则进行抗阻训练,进行4 周的低氧及抗阻训练干预后测试各组大鼠体成分,比目鱼肌?趾长伸肌?腓肠肌?肱二头肌的湿重和肌纤维横截面积?结果 观察到HR 组瘦体重显著高于H 组,H 组瘦体重显著低于C 组; HR 组的肱二头肌湿重和肌纤维横截面积显著高于H 组?结论 抗阻训练有助于预防低氧诱导骨骼肌萎缩的发生,爬梯形式的抗阻练习可刺激大鼠肱二头肌的肥大?
英文摘要:
      Objective To explore the effects of resistance training on hypoxia?induced skeletal muscle atrophy in rats and provide a theoretical basis to solve the problem of skeletal muscle atrophy of athletes in altitude training. Methods 24 male 8?week?old SD rats (mean body weight 230 g) were divided into 4 groups: normoxia control group (C), resistance training group (R), hypoxia group (H) and hypoxia and resistance training group (HR). The groups H and HR were placed into environment simulated 4000 m altitude (12. 4%, O2 %). Moreover, the groups R and HR received resistance training. After the 4?week hypoxia and resistance training intervention, the body composition, wet weight of skeletal muscle (soleus, musculus gastrocnemius, extensor digitorum longus and musculus biceps brachii) and skeletal muscle cross?sectional area (CSA) were measured and analyzed. Results The muscle mass of HR group was significantly higher than the group H ( P < 0. 01). The wet weight and CSA of musculus biceps brachii in the group HR were also significantly higher than the group H ( P < 0. 05). Conclusions Resistance training can help to prevent the occurrence of hypoxia?induced skeletal muscle atrophy. Resistance ladder training can stimulate the hypertrophy of biceps brachii.
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