Abstract:Abstract: Objective A rat model of liver metabolism profile in chronic heart failure (CHF) was established for exploration of the dynamics of liver metabolism in CHF from the perspective of metabolism, in search for the characteristic metabolites significant for the molecular mechanism and management of CHF. Methods 20 male Wistar rats were assigned to the CHF group to receive aortic coarctation or to the control group to receive sham surgery, and were bred for 24 weeks following surgery. Metabolic profiling was performed on the rat liver tissues on a metabonomics research platform. Orthogonal partial least squares-discriminant analysis (OPLS-DA) model and principal component analysis (PCA) model were established for liver tissues of CHF rats, and the characteristic metabolites were finally derived by data processing with SPSS 19.0 software. Results The PAC and OPLS-DA models were established successfully. 10 characteristic metabolites with differences between the CHF and control groups, e.g., lysophosphatidyl choline, lysophosphatidyl ethanolamine, oleic acid, glycocholic acid, and dehydroepiandrosterone sulfate, were screened and identified from the models. Conclusion The metabolic disorders in CHF rats were well fitted to the metabolic profile models established, and the characteristic metabolites identified could provide reference for the patho-physiological molecular mechanism and management, etc., of CHF.