Therapeutic effect and mechanism of Guizhi Fuling decoction on endometrial carcinoma
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(1. The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.2. Guangdong Medical Laboratory Animal Center, Foshan 528248)

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R-33

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    Abstract:

    Objective To observe the effects of treatment with Guizhi Fuling decoction on human endometrialcarcinoma HEC-1-B cancer in unde mouse models. Methods HEC-1-B cancer model nude mice were divided into threegroups. The model group received intragastric gavage of deionized water, the Guizhi Fuling decoction group receivedintragastric gavage of 2. 4 g/ kg Guizhi Fuling decoction, and the carboplatin injection group received a single intraperitonealinjection of 20 mg/ kg carboplatin. Results Both Guizhi Fuling decoction and carboplatin injection significantly reducedthe HEC-1-B tumor volume ( P <0. 05). Guizhi Fuling decoction promoted the expression of caspase-3 and reduced the expression of Bcl-2 protein. Conclusions Guizhi Fuling decoction has inhibitory effects on endometrial cancer.

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History
  • Received:June 25,2018
  • Revised:
  • Adopted:
  • Online: April 10,2019
  • Published: