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李瑞生.BALB/c突变卷毛小鼠部分生长发育指标初探[J].中国比较医学杂志,2013,23(11):0.
BALB/c突变卷毛小鼠部分生长发育指标初探
Analysis of Partial Growth index in BALB/c Mutant Curly Mice
投稿时间:2013-10-09  修订日期:2013-10-25
DOI:
中文关键词:  BALB/c小鼠  突变卷毛  生长发育
英文关键词:BALB/c mice  Mutant curly  Growth index
基金项目:
作者单位E-mail
李瑞生 解放军第302医院 lrsheng@sohu.com 
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中文摘要:
      目的 利用近交培育建立BALB/c突变卷毛小鼠模型,分析突变小鼠与正常小鼠间生长发育和脏器系数的突变差异。方法 选择21d、42d和63d三个不同日龄组的BALB/c突变卷毛小鼠和正常BALB/c小鼠各20只,雌雄各半,分别测量体质量、头长、体长、尾长及主要脏器质量,计算头体比、尾体比及脏器系数并进行对比分析。结果 F4代的BALB/c突变卷毛小鼠已完全纯合。21d和42d突变卷毛小鼠头体比和尾体比小于正常小鼠(P<0.05);63d突变卷毛小鼠的体质量、头体比和尾体比均小于正常小鼠(P<0.05)。21d突变卷毛小鼠的心脏、脾脏、卵巢、子宫系数均大于正常小鼠(P<0.05,P<0.01);42d突变卷毛小鼠的心脏和胸腺系数低于正常小鼠,脑和睾丸系数高于正常小鼠(P<0.05,P<0.01);63d突变卷毛小鼠的心脏和子宫系数低于正常小鼠,脑系数高于正常小鼠(P<0.05,P<0.01)。结论 BALB/c突变卷毛小鼠与正常小鼠的外观特征和脏器系数均存在差异,这些突变差异对于研究BALB/c突变卷毛小鼠的生长发育、心血管系统、免疫系统和生殖系统都具有十分重要的意义。
英文摘要:
      Objective To analyze the difference of growth and organ coefficient between mutant mice and normal mice using inbred BALB/c curly mutant mouse model.Methods 21d,42d and 63d three different age groups of BALB/c mutant curly and normal BALB/c mice of 20 each,half male and half female,were selected to measure body weight,head length,body length,tail length and to compare the head body ratio,tail body ratio and organ coefficient.Results F4 generation BALB/c mutant curly has completely homozygous mice.Head body ratio,tail body ratio of mutant curly mice aged 21d and 42d were lower than those of normal mice (P< 0.05),body weight,head body ratio,tail body ratio of mutant curly mice aged 63d were lower than those of normal mice (P< 0.05).Heart,spleen,ovarian,uterine coefficient of 21d mutant mice were greater than those of normal mice (P< 0.05,P<0.01);heart and thymus coefficient of 42d mutation curly mice were lower than those of normal mice,brain and testis coefficient were higher than those of normal mice (P< 0.05,P< 0.01);heart and uterus coefficient of 63d mutant curly mice lower than those of normal mice,brain coefficient was higher than those of normal mice (P<0.05,P< 0.01).Conclusion There are differences in appearance and organ coefficient of BALB/c mutant curly and normal mice,these different mutations have very important significance for the study of BALB/c mutant curly mice growth,cardiovascular system,immune system and reproductive system.
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