Online teaching of laboratory animal science during the COVID-19 epidemic situation is an effective supplement and improvement to the traditional teaching model. It is necessary to know the operation of network software packages and apply them to realize the transformation of teaching consciousness. Teachers should maintain continuity of teaching ideas, focusing on the presentation of PPT, and demonstrate animal experimental operations using the existing Massive Open Online Course (MOOC) resources. All efforts are to teach students how to effectively master the content of lectures in the network environment. Moreover, the content related to COVID - 19, especially for animal experiments, should be included in lectures to stimulate the students’ interest in learning. We should also improve course evaluation method , promote the reform of laboratory animal science teaching, and constantly enrich the teaching model of laboratory animal science.