中药调节肠道菌群降低血糖的作用及机制研究进展
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1.广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室, 广州 510260; 2.华南农业大学实验动物中心,广州 510642

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R-33

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Progress in the understanding of the roles and mechanisms of Traditional Chinese Medicine in lowering blood glucose by regulating gut microbiota
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1.Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou 510260,China. 2. Laboratory Animal Center of South-China Agricultural University, Guangzhou 510642

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    摘要:

    2 型糖尿病(Type 2 diabetes mellitus, T2DM)是一种威胁患者健康的代谢性疾病,现代医学以控制血糖稳定与预防并发症为主要治疗手段,患者需要终生服用降糖药。化学药疗效确切,但长期服用后容易引发系列的副作用,严重的限制了其推广和使用。中药(Traditional Chinese Medicine,TCM)降血糖的历史悠久,在 T2DM 这类复杂疾病的治疗中独具优势,但其作用机制尚不十分清楚。最新研究表明,TCM 可以通过调节肠道菌群来改善葡萄糖代谢从而降低血糖,这给 T2DM 的防治提供了新的方法和思路。本文综述 TCM 及其有效成分、复方制剂通过调节肠道菌群降低血糖的作用及机制最新进展,为后续开展 TCM 降血糖研究提供参考和建议。

    Abstract:

    Type 2 diabetes mellitus (T2DM) is a metabolic disease that seriously threatens the health of patients. Modern medicine is mainly used to control blood sugar stability and prevent T2DM complications. T2DM patients are required to take hypoglycemic agents for life. Although chemical drugs have a definite curative effect, they also cause several side effects after long-term use, which seriously limits their use. Traditional Chinese medicine (TCM) has a long history of blood glucose-lowering abilities, and it has unique advantages in the treatment of complex diseases ( i. e., T2DM), but its mechanism is not fully understood. Recent studies have shown that TCM can lower blood glucose by regulating gut microbiota to improve glucose metabolism, which provides new method and ideas for the prevention and treatment of T2DM. This article reviews the recent progress in the understanding of the roles and mechanisms of TCM, its extracts, and compound preparations to lower blood glucose by regulating gut microbiota. We also provide references and recommendations for future research on the blood glucose-lowering ability of TCM.

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唐明甜,肖百全,刘忠华,饶军华.中药调节肠道菌群降低血糖的作用及机制研究进展[J].中国比较医学杂志,2020,30(5):120~126.

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  • 收稿日期:2019-10-28
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  • 在线发布日期: 2020-06-19
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自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
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