Research progress regarding Na+ / K+ -ATPase activity in individuals with epilepsy
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Department of Neurology, First Affiliated Hospital of Kunming Medical University,Kunming 650032,China
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摘要:
癫痫是神经系统常见慢性病,无规律反复发作对患者及其家庭造成极大困扰。钠钾 ATP 酶(Na+ , K+-ATPase,NKA)是哺乳动物细胞膜上广泛存在的跨膜蛋白,对细胞内外离子梯度的维持、神经递质的释放与再摄 取、能量代谢起至关重要的作用。在癫痫脑内,NKA 的活性变化尤为突出而复杂,癫痫发作后 NKA 活性明显降低, 但过度调节钠钾 ATP 酶活性又影响癫痫易感性。 本文就近年来 NKA 分型、分布、功能,及其活性与癫痫发作间的 相互调控和可能的机制等方面的研究进展做一综述。
Abstract:
Epilepsy is a relatively common chronic neurological condition that is often characterized by unprovoked recurrent seizures that can be very disruptive for the lives of patients and their families. Na+ / K+ -ATPase (NKA) is a transmembrane protein distributed widely in most cells of mammalian animals. NKA is critical for the maintenance of the ionic gradient between intracellular and extracellular space, the uptake and release of neurotransmitters, and energy metabolism. Complicated patterns of change in NKA activity have been observed in the brains of epileptic patients and animals. Excessive changes in NKA activity may upregulate susceptibility to epilepsy in non-human animals, although NKA activity decreases significantly after recurrent seizures. In this article, we reviewed the classification, distribution, and function of NKA, as well as interactions and possible mechanisms between NKA activity and seizures.
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杜孙兵,杨文秋,吴 倩,韩雁冰.钠钾 ATP 酶活性与癫痫发作的研究进展[J].中国比较医学杂志,2020,30(5):108~113.