不同年龄雌性恒河猴肾多模式分子功能影像的观察
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(1.昆明医科大学第一附属医院核医学科,昆明 650032; 2.中国人民解放军联勤保障部队第九二〇医院干细胞与免疫细胞生物医药国家地方联合工程实验室、云南省细胞治疗技术转化医学重点实验室,昆明 650032; 3.中国科学院昆明动物研究所,昆明 650223)

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R-33

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Observation of renal multi-mode molecular function imaging in female rhesus monkeys of different ages
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(1. Department of Nuclear Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.2. Yunnan Provincial Key Laboratory of Cell Therapy and Translational Medicine, National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, 920th Hospital of Joint Logistics Support Force of PLA, Kunming 650032. 3. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223)

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    摘要:

    目的 观察不同年龄组雌性恒河猴肾的GFR?ADC?SUV?CT 值等多种影像学指标,探究年龄对雌性恒河猴肾多种影像学定量指标的影响?方法 选取不同年龄雌性恒河猴17 只,按年龄分为幼年组?成年组?老年组?检测每只恒河猴血液BUN?Cre?UA 水平?进行SPECT/ CT?MRI?PET/ CT 等多模式分子功能显像并通过工作站测量GFR?ADC?SUVmax?SUVmean?CT 值?左右肾间指标比较采用t 检验,不同年龄组间肾指标采用方差分析?肾功能血清学指标与GFR 的相关性采用Pearson 分析?结果 雌性恒河猴老年组的左右肾小球滤过率(GFRL?GFRR)和总肾小球滤过率(GFRtotal)以及ADC 值均显著低于成年组和幼年组( P <0. 05),GFRL?GFRR?GFRtotal 以及ADC 值在各年龄组内左右肾间均无显著性差异( P >0. 05)?SUVmax?SUVmean?CT 值在各年龄组内左右肾间及三个年龄组间均无显著性差异( P >0. 05)?BUN?Cre?UA 在三个年龄组间均无显著性差异( P >0. 05)?相关性分析结果显示,BUN?Cre 均分别与GFRtotal 呈现中度相关性(r = 0. 56,-0. 56, P <0. 05)?UA 与GFRtotal 无显著相关性( P >0. 05)?结论 该研究通过SPECT/ CT 分子功能影像为恒河猴左右分肾功能定量分析提供了参考依据,作为分肾功能“金标准”评价为恒河猴肾相关科学实验研究提供基础资料?

    Abstract:

    Objective To observe various indexes (GFR, ADC, SUV, and CT value) of the kidney of femalerhesus monkey in different age groups, and explore the influence of age on these indexes. Methods Seventeen femalerhesus monkeys of different ages were selected and divided into juvenile, adult, and old groups. BUN, Cre, and UA weredetected in each rhesus monkey. SPECT/ CT, MRI, and PET/ CT were performed and GFR, ADC, SUVmax, SUVmean, andCT values were measured by workstation. A t test was used for comparison of indicators of left and right kidneys, whileANOVA was used for renal indicators among different age groups. Correlations between renal serologic indicators and GFRwere analyzed by Pearson analysis. Results GFRL, GFRR, GFRtotal, and ADC values in old female rhesus monkeys weresignificantly reduced compared with adult and juvenile groups ( all P < 0. 05). However, there were no significantdifferences in GFRL, GFRR, GFRtotal, or ADC values between the left and right kidneys of all age groups (all P > 0. 05).There were no significant differences in SUVmax, SUVmean, or CT values between the right and left kidneys of each agegroup, or among the three age groups (all P > 0. 05). BUN, Cre, and UA were not significantly different among the threeage groups (all P > 0. 05). Correlation analysis results showed that BUN and Cre were moderately correlated with GFRtotal(r=0. 56, -0. 56, all P < 0. 05). However, there was no significant correlation between UA and GFRtotal ( P > 0. 05).Conclusions This study provides a reference for quantitative analysis of rhesus monkey renal function by SPECT/ CTmolecular functional imaging, and provides basic data for scientific experiments involving rhesus monkey kidney as the gold standard for evaluation of renal function.

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王梓延,何蕊,谢飞,林庆铿,王娇,胡建伟,潘兴华,朱高红,吕龙宝.不同年龄雌性恒河猴肾多模式分子功能影像的观察[J].中国比较医学杂志,2019,29(9):26~31.

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  • 收稿日期:2019-05-05
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  • 在线发布日期: 2019-10-10
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