Graves’ disease (GD), the most common clinical type of hyperthyroidism, is a common organ-specificautoimmune disease. Although its etiology involves genetic and environmental factors, the exact pathogenesis of GD remainsunclear. Extensive genome-wide association studies ( GWAS) have identified various genes that contribute to thedevelopment of GD. This article reviews progress in our identification of susceptibility genes for GD, and provides a preliminary discussion on the genetic mechanism that promote GD onset.