3M 组织胶和电凝止血在尿毒症大鼠肾切除的应用
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(广西医科大学第一附属医院,南宁 530021)

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R-33

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Application of 3M vetbond tissue adhesive and electrocoagulation in nephrectomy in a rat model of uremia
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(The first affiliated hospital of guangxi medical university,Nanning 530021,China)

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    目的 对比两种止血方法在大鼠尿毒症模型的应用?方法 雄性SD 大鼠分为A?B 两组,均采用左肾2/3 切除加右肾切除制作尿毒症模型?A 组左肾2/3 切除时采用3M 组织胶止血,B 组采用电凝止血,术中比较出血量?左肾血流阻断时间,术后对比大鼠的存活率,测肌酐值,以达到正常血肌酐值2 ~3 倍者为尿毒症大鼠模型?肾脏组织行病理检查?结果 两种止血方法的血肌酐均升高达尿毒症模型要求;A 组左肾血流阻断时间为(59. 97±7. 56)s,B 组为(174. 1±15. 28)s( P <0. 05);A 组左肾切除的出血量为(0. 11±0. 037)mL,B 组为(0. 24±0. 056)mL( P <0. 05);两组肾组织病理学均提示肾小球缺血皱缩?小管间质纤维化;A 组的术后存活率明显高于B组( P <0. 05)?结论 3M 组织胶无论是出血时间?出血量,还是术后存活率均优于电凝止血?

    Abstract:

    Objective To compare the effects of two hemostatic methods including 3M vetbond tissue adhesiveand electrocoagulation in a rat model of uremia. Methods Male SD rats were divided into groups A and B. To induce theuremia model, all rats underwent right and 2/3 left kidney resection. 3M vetbond tissue adhesive was used in the group Afor hemostasis, while electric coagulation was used in group B. The amount of bleeding and the duration of left renal bloodflow blockage during operation were assessed. The postoperative survival rates of the two groups were compared. Thecreatinine values of all rats after operation were measured, and rats for which the creatinine value was two to three timeshigher than normal were further regarded as a uremic model. Kidney tissues were examined by pathology. Results Theserum creatinine after the application of both hemostatic method after 5/6 renal resection was 2-3 times higher than thenormal level. Left renal blood flow blockage of group A was (59. 97 ±7. 56) s and that of group B was (174. 1±15. 28) s( P <0. 05). The blood loss of the group A during left renal resection was (0. 11±0. 037) mL, and that of group B was(0. 24 ±0. 056) mL ( P <0. 05). Pathology of renal tissues in both groups indicated glomerular ischemic shrinkage andtubular interstitial fibrosis. The postoperative survival rate of group A was significantly higher than that of the group B ( P <0. 05). Conclusions 3M vetbond tissue adhesive is more effective than electrocoagulation to shorten the bleeding time,decrease the bleeding amount, or increase the postoperative survival rate.

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黄海燕,李福记,林鹏,廖蕴华.3M 组织胶和电凝止血在尿毒症大鼠肾切除的应用[J].中国比较医学杂志,2019,29(4):41~45.

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  • 收稿日期:2018-09-27
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  • 在线发布日期: 2019-05-10
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