Laboratory animal science mainly consists of experimental animals and animal experiments. It is an indispensable part of medical science research. To meet the needs of cultivating innovative talent at the undergraduate stage of higher education, the Ministry of Education has implemented the innovation and entrepreneurship training program for national college students during the “12th Five-Year” period, and more undergraduate students are able to participate in scientific research directly. Therefore, experimental zoology courses start at the undergraduate stage of Chinese medicine colleges and universities to improve undergraduate students. The ability to perform scientific research is more important than ever. The curriculum adopts a variety of teaching modes in class. It introduces the concept of experimental animals, the anatomical and physiological characteristics of common experimental animals, animal experiment design, methods of animal disease model establishment, and the principles of genetic engineering for animal model establishment. It strengthens the process of evaluating student learning, optimizes the method of evaluation, and improves the ability of students. This learning initiative lays the foundation for successful completion of scientific research by undergraduates.