Objective The purpose of this study was to investigate the effects of rose and cream on fiber pressure ulcer granulation tissue in rat models of pressure ulcer in terms of adhesion protein (fibronectin, FN) and basic fibroblast growth factor (BFGF) levels and their associated mechanisms. Methods A total of 128 SD rats were randomly selected for groups as follows: 32 in the sham operation group and the other 96 for groups with rat bilateral gluteal muscle implanted under the external magnetic disk compression cycle method of ischemia reperfusion to establish stage III model. After 4 days, these 96 were randomly divided into a model group, a positive control group, and a rose and cream group. The sham operation group and model group were treated with physiological Shiomizu Sabu, the positive control group was treated with hydrocolloids, and the rose and cream group had Guiji cream gauze applied to bedsores. At the end of treatment, bedsore wound healing rate and healing speed were analyzed upon treatment for 3, 7, 14, and 21 d, along with determination of the levels of rat tail vein blood serum inflammatory cytokines interleukin?1 beta ( IL?1β), IL?6, and C?reactive protein (CRP), and ELISA for FN and BFGF to determine the level of pressure ulcer granulation tissue, by the solid?phase sandwich method . Results The effective time and healing time of the rose and cream group were shorter than those of the positive control group, and the healing rate and healing speed of the cream group were higher than those of the positive control group ( P < 0. 05). Upon treatments for 14, 21, and 28 d, the rose and cream group venous blood CRP, IL?1β, and IL?6 levels were significantly lower than those of the model group and the positive control group ( P < 0. 05), while BFGF and FN were significantly higher than those of the model group and positive control group ( P < 0. 05). Conclusions Rose and cream may reduce wound injury by inhibiting the inflammation caused by the ulcer wound inflammatory mediators IL?6 and IL?1β, increasing the synthesis of BFGF and FN to promote cell proliferation and extracellular matrix synthesis of stromal cells, promoting wound granulation tissue of newborns, and accelerating wound tissue repair.