Research progress of ciRS-7 in cardiovascular diseases
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(The Second Affiliated Hospital, Zhujiang Hospital, Sounthern Medical University, Guangzhou 510282, China)
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摘要:
心血管疾病目前仍居世界各国死因首位,其发病率和死亡率仍呈增长趋势?最新研究表明,环状RNA(circular RNA,circRNA)参与调控基因的转录与翻译,在心血管系统疾病的进展过程中发挥重要的作用?ciRS-7(circular RNA sponge for miR-7,ciRS-7)是一类特殊的环状RNA,其能够在转录或转录后水平对基因表达进行调控,继而调控多种生命活动,与心血管系统疾病密切相关,成为RNA 领域最新的研究热点?如今,circRNA 在心血管疾病的发生发展?早期诊断?病程监控等方面的作用受到越来越多的重视?文中将以ciRS-7 为重点,从circRNA 的发生机制?功能及与其与心血管疾病的关系等方面对最新国内外的研究进展作一综述?
Abstract:
Cardiovascular disease is still the world’s first cause of death, its morbidity and mortality rates are still increasing. Recent studies have shown that circular RNA is involved in the regulation of gene expression and plays a significant role in the pathogenesis of cardiovascular diseases. Circular RNA is a kind of special non-coding RNA, which can regulate the expression of genes at the level of post-transcription or transcription, then regulate various life activities as well as cardiovascular system diseases, becoming a latest research hot spot in the field of RNA. Nowadays, more and more attention is paid to the role of cyclic RNA in the development, early diagnosis, disease monitoring and other aspects of cardiovascular diseases. In this paper, we make an overview of the latest research on circRNAs from the aspects of genesis, function, and the relationship with cardiovas cular diseases, and so on.