| 李彦红,刘颖,秦川.免疫衰老与T、B细胞改变的相关研究[J].中国比较医学杂志,2012,(6):65~71. |
| 免疫衰老与T、B细胞改变的相关研究 |
| Correlational Research of Immunosenescence and the Change of T、B Cell |
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| DOI：10.3969/j.issn.1671.7856.2012.06.015 |
| 中文关键词: 免疫衰老 适应性免疫 T、B细胞 分子 |
| 英文关键词:Immunosenescence Adaptive immunity T,B cell Molecule |
| 基金项目:协和青年科研基金(慢性炎症性皮肤病KM小鼠自发突变模型的研究和培育)。 |
| 作者 | 单位 | E-mail | | 李彦红 | 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 | liyanhong8408@163.com | | 刘颖 | 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 | | | 秦川 | 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 | |
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| Author Name | Affiliation | E-mail | | LI Yan-hong | Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health
Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences
Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine
Beijing Union Medicine College, Beijing 100021, China | liyanhong8408@163.com | | LIU Ying | Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health
Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences
Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine
Beijing Union Medicine College, Beijing 100021, China | | | QIN Chuan | Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health
Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences
Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine
Beijing Union Medicine College, Beijing 100021, China | |
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| 中文摘要: |
| 胸腺、适应性免疫系统的T、B细胞及固有免疫系统中中性粒细胞、巨噬细胞、NK/NKT细胞、树突状细胞等免疫细胞与免疫衰老(immunosenescence)均存在一定相关性。免疫衰老主要涉及适应性免疫系统的改变,本文将从T、B细胞的数目、功能、表面分子、分泌的细胞因子及其信号转导等方面的改变进行总结。 |
| 英文摘要: |
| There are some correlations between the variation of thymus,T、B cells of adaptive immune system, neutrophil, macrophage, NK/NKT cells, Dendritic cells etc of natural immune system and immunosenescence. Immunosenescence mainly associated with the varies of adaptive immune system, therefor, this article will introduce the inordinately varies of the number, surface molecules, cytokines and signal transduction as well as the dysfunction of T and B cell with age. |
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