Alzheimer"s disease is a progressive neurodegenerative disorder characterized primarily by memory loss, cognitive impairment, language dysfunction, and loss of behavioral abilities in its later stages. Due to its complex pathogenesis, there are currently no effective treatments available. Abnormal epigenetic modifications are closely associated with the onset and progression of AD. Histone methylation is one of the important epigenetic modifications, which participates in the pathological process of AD by dynamically regulating chromatin structure and gene transcription. It plays an important regulatory role in the formation of Aβ plaques, hyperphosphorylation of tau protein, neuroinflammation, synaptic plasticity, and neuronal death.Traditional Chinese medicine has unique advantages in the prevention and treatment of AD. Research shows that traditional Chinese medicine and its active ingredients can regulate histone methylation to improve AD, mainly by reducing the production of Aβ and highly phosphorylated tau protein, alleviating neuroinflammatory responses, repairing synaptic plasticity damage, and increasing neuronal survival. This paper reviews the key role of histone methylation in AD and the intervention research on traditional Chinese medicine and its active ingredients based on the current state of research at home and abroad, providing theoretical support for the clinical treatment and scientific research of AD, as well as new ideas for the scientific connotation of the modernization of traditional Chinese medicine.