Alzheimer's disease (AD) is an age-related neurodegenerative disease, which is mainly manifested clinically as progressive cognitive impairment and memory and language function impairment. With the acceleration of the aging process of China's population, the number of people suffering from AD in China is also increasing. The exact pathogenesis of AD is still unclear, and the current treatment strategy is mainly symptomatic treatment. Animal models are important tools for preclinical research, which are used to explore the molecular mechanism, behavioral function and treatment strategy of the disease. In the future, the mechanism research and drug development of AD need to establish animal models that are consistent with clinical pathological characteristics. This article mainly summarizes the AD animal models commonly used in research reports in recent years, and elaborates on the strains, age, modeling methods, modeling doses, research on Chinese medicine components and pharmacodynamic mechanisms of related AD animal models, in order to provide some references for the establishment of new animal models in the future or for in-depth exploration of the specific pharmacological activities, targets, metabolic pathways and clinical applications of each component in Chinese medicine.