基于数据挖掘的血管再狭窄动物模型分析
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作者单位:

1.中国中医科学院西苑医院;2.北京中医药大学

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基金项目:

中国中医科学院科技创新工程(CI2021A00910);国家自然科学基金(81973674);


Analysis of Vascular Restenosis Animal Model Based on Data Mining
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Affiliation:

1.Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine;2.Beijing University of Chinese Medicine

Fund Project:

Science and Technology Innovation Project of Chinese Academy of Traditional Chinese Medicine (CI2021A00910); National Natural Science Foundation of China (81973674)

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    摘要:

    目的:对近10年血管再狭窄动物模型的造模方法和评价手段等进行分析统计,为完善血管再狭窄动物模型提供参考。方法:检索2013-2023年中英文主流数据库中的血管再狭窄相关文献,提取纳入文献中的实验动物品系、造模方式、造模周期及检测方式等数据,通过Excel建立数据库进行汇总分析。结果:纳入符合标准的122篇文献中,实验动物品系以大鼠、兔和猪为主,性别以雄性为主,最常用的造模方式为球囊拉伤术,造模周期主要在4W-8W之内,检测指标以组织病理学为主,占37.18%,包括常规苏木精-伊红染色、Masson染色、EVG染色等。结论:目前猪的血管再狭窄模型翻译转化性较符合预期,但成本较高,难以推广,使用大鼠和兔仍占主流,造模方式以球囊拉伤术为主,不同血管再狭窄动物模型和造模方式各有利弊,应根据实验目的进行选择。血管再狭窄动物模型仍有一定局限性,未来寻求更理想的动物模型势在必然。

    Abstract:

    Objective: To analyze the modeling methods and evaluation methods of vascular restenosis animal model in recent 10 years, and provide reference for improving vascular restenosis animal model. Methods: Literature related to vascular restenosis was retrieved from Chinese and English mainstream databases from 2013 to 2023. Data of experimental animal strain, modeling method, modeling cycle and detection method were extracted from the included literature, and a database was established by Excel for summary analysis. Results: Among the 122 articles, the experimental animal strains were mainly rats, rabbits and pigs, and the sex was mainly male. The most commonly used modeling method was balloon injury, and the modeling cycle was mainly within 4W-8W. The detection indexes were mainly histopathology, accounting for 37.18%, including routine hematoxylin-eosin staining, Masson staining and EVG staining. Conclusion: At present, the translatability of porcine vascular restenosis model is more in line with expectations, but the cost is high and it is difficult to popularize. Rats and rabbits are still the mainstream. Balloon injury is the main mode of modeling. Different vascular restenosis animal models and modeling methods have advantages and disadvantages, and should be selected according to the experimental purpose.Animal models of vascular restenosis still have some limitations, and it is inevitable to seek more ideal animal models in the future.

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  • 收稿日期:2024-08-26
  • 最后修改日期:2024-11-19
  • 录用日期:2025-02-18
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